Adult cardiac surgery, adult heart transplantation.
Advanced engineering analysis of cardiac function in the setting of ischemic coronary artery disease, valvular heart disease and dilated cardiomyopathy. These analyses include 3D stress/strain characterization of the human left ventricle.
Innovative algorithms for next generation ventricular assist device development.
Michael K. Pasque is Professor of Surgery, Division of Cardiothoracic Surgery at Washington University School of Medicine. Dr. Pasque received his M.D. degree from the University of Oklahoma. He completed a residency in general surgery at the University of California-Los Angeles and a residency in cardiothoracic surgery at the University of Toronto. He also completed a two-year cardiac physiology research fellowship in the Department of Surgery at Duke University. He is certified by the American Board of Thoracic Surgery.
Dr. Pasque has been the Principal Investigator on NIH-funded grants for over 20 consecutive years. During this period of uninterrupted NIH funding, his laboratory effort has developed and validated a methodology to apply advanced mathematical and engineering analyses to MRI-based cardiac geometrical datasets acquired from patients in the clinical setting. These advanced MRI-based multiparametric strain analyses have been clinically applied in patient subsets with a wide range of cardiovascular disease states including ischemic, valvular, and dilated cardiomyopathies. Besides his own NIH funding, his laboratory has been the primary setting for funded NIH grants from three other investigators in the Division, in addition to a career-long collaboration with multiple NIH-funded investigators from departments across the Washington University campuses. Parallel to this primary area of research, Dr. Pasque has also been active in the design, development, and testing of innovative ventricular assist devices with a wide range of industry partners. Dr. Pasque takes an active role in the education and mentoring of cardiothoracic fellows. His primary clinical role is now centered in donor organ procurement for heart and lung transplantation.
Pub Med page for Michael K. Pasque, M.D.
Pasque MK. Standardizing thoracic organ procurement for transplantation. J Thorac Cardiovasc Surg. 2010 Jan;139(1):13-7.
Joseph S, Moazami N, Cupps BP, Howells A, Craddock H, Ewald G, Rogers J, Pasque MK. Magnetic resonance imaging-based multiparametric systolic strain analysis and regional contractile heterogeneity in patients with dilated cardiomyopathy. J Heart Lung Transplant. 2009 Apr;28(4):388-94.
Cupps BP, Bree DR, Wollmuth JR, Howells AC, Voeller RK, Rogers JG, Pasque MK. Myocardial viability mapping by magnetic resonance-based multiparametric systolic strain analysis. Ann Thorac Surg. 2008 Nov;86(5):1546-53.
Bree D, Wollmuth JR, Cupps BP, Krock MD, Howells A, Rogers J, Moazami N, Pasque MK. Low-dose dobutamine tissue-tagged magnetic resonance imaging with 3-dimensional strain analysis allows assessment of myocardial viability in patients with ischemic cardiomyopathy. Circulation. 2006 Jul 4;114(1 Suppl):I33-6.
Pomerantz BJ, Wollmuth JR, Krock MD, Cupps BP, Moustakidis P, Kouchoukos NT, Davila-Roman VG, Pasque MK. Myocardial systolic strain is decreased following aortic valve replacement in patients with aortic insufficiency. Ann Thorac Surg 2005 Dec;80(6):2186-92.
Moustakidis P, Maniar HS, Cupps BP, Absi T, Zheng J, Guccione JM, Sundt TM, Pasque MK. Altered LV geometry changes the border zone temporal distribution of stress in an experimental model of LV aneurysm: a finite element model study. Circulation. 2002;106:I168-I175.
Pasque MK. Mathematic modeling and cardiac surgery. J Thorac Cardiovasc Surg. 2002;123(4):617-20.
Pasque MK. A different kind of “Total Artificial Heart”: The interactive Computer-Based Human Heart Model. Ann Thorac Surg. 2002;73(4):1032-1034.
Guccione JM, Moonly SM, Moustakidis P, Costa KD, Moulton MJ, Ratcliffe MB, Pasque MK. Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study. Ann Thorac Surg. 2001 Feb;71(2):654-62.
Moulton MJ, Creswell LL, Downing SW, Ungacta FF, Hu N, Szabo BA, Pasque M. Magnetic resonance imaging provides evidence for remodeling of the right ventricle after single lung transplantation for pulmonary hypertension. Circulation 1996 Nov;94:9.
Moulton MJ, Creswell LL, Downing SW, Actis RL, Szabo BA, Vannier MW, Pasque MK: Spline surface interpolation for calculating 3-D ventricular strains from MRI tissue tagging. Am J Physiol. 1996; 270 (Heart Circ Physio, 39):H281-H297.
Pasque MK, Trulock EP, Cooper JD, Triantafillou AN, Huddleston CB, Rosenbloom MR, Sundaresan Sudhir, Cox JL, Patterson GA. Single lung transplantation for pulmonary hypertension: single institution experience in 34 patients. Circulation. 1995;92(8):2252-2258.
Moulton MJ, Creswell LL, Actis RL, Myers KW, Szabo BA, Vannier MW, Pasque MK. An inverse approach to determining myocardial material properties. J Biomechanics. 1995; 28:935-948.
Creswell LL, Wyers SG, Pirolo JS, Moulton MJ, Perman WH, Myers KW, Actis RL, Vannier MW, Szabo BA, Pasque MK. An experimental method for evaluating constitutive models of the myocardium in the in vivo heart. Am J Physiol. 1994; 267 (Heart Circ Physiol 36): H853-H863.
Pasque MK, Cooper JD, Kaiser LR, Haydock DA, Triantafillou A, Trulock EP. An improved technique for bilateral lung transplantation: rational and initial clinical experience. Ann Thorac Surg. 1990;49:785-791.