Alexander S. Krupnick, MD

Alexander S. Krupnick, MD

  • Associate Professor of Surgery

Medical School

M.D., The University of Michigan Medical School, Ann Arbor, Michigan, 1996.

Post Doctoral Education

Intern in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1996-1997

Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1997-1999

Surgical Research Fellow, Harrison’s Department of Surgical Research, Hospital of The University of Pennsylvania, 1999-2002

Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 2002-2004

Thoracic Transplant Fellow, Washington University in St. Louis, 2004-2005

Thoracic Surgery Fellow, Barnes-Jewish Hospital, Washington University in St. Louis, 2005-2007

Board Certifications

General Surgery -- Certified
Thoracic Surgery -- Certified

Clinical Interests

Thoracic oncology, minimally invasive thoracic surgery, lung transplantation, immunotherapy.

Research Interests

Tumor immunology

See Washington University Thoracic Immunology Lab website.

Patients Seen At

Center for Advanced Medicine
Jacqueline Maritz Lung Center
4921 Parkview Place, Suite B, Floor 8
St. Louis, MO 63110
(314) 362-9181

Selected Publications

Vikis HG, Gelman AE, Franklin A, Stein L, Rymaszewski A, Zhu J, Liu P, Tichelaar JW, Krupnick AS, You M. Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. Molecular Carcinigenesis. 2011 Oct 17. [Epub ahead of print] PMID: 22006501

Krupnick AS, Tidwell VK, Engelbach JA, Gelman, AE, Kreisel D, Alli, V, Nehorai A, You M, Vikis H, Garbow J. Quantitative monitoring of murine lung tumors by magnetic resonance imaging. Nature Protocols. 2011 (in press)

Puri V, Meyers BF, Kreisel D, Patterson GA, Crabtree TD, Battafarano RJ, Krupnick AS. Sternoclavicular joint infection: a comparison of two surgical approaches. Ann Thorac Surg. 2011 Jan;91(1):257-61.

Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS, Carmody RJ, Gelman AE. Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis. J Clin Invest. 2010 Dec 13.[Epub ahead of print] PMID: 21157041

Kreisel D, Krupnick AS, Puri V, Guthrie TJ, Trulock EP, Meyers BF, Patterson GA. Short- and long-term outcomes of 1000 adult lung transplant recipients at a single center. J Thorac Cardiovasc Surg. 2010 Nov 18. [Epub ahead of print] PMID: 21093882

Kreisel D, Lai J, Richardson SB, Ibricevic A, Nava RG, Lin X, Li W, Kornfeld CG, Miller MJ, Brody SL, Gelman AE, Krupnick AS. Polarized alloantigen presentation by airway epithelial cells contributes to direct CD8+ T cell activation in the airway. Am J Respir Cell Mol Biol. 2011 Jun;44(6):749-54.

Kreisel D, Richardson SB, Li W, Lin X, Kornfeld CG, Sugimoto S, Hsieh CS, Gelman AE, Krupnick AS. Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses. J Immunol. 2010 Oct 1;185(7):3809-1

Murala S, Alli V, Kreisel D, Gelman AE, Krupnick AS. Current status of immunotherapy for the treatment of non-small cell lung cancer. Journal of Thoracic Disease. 2010 Dec;2:237-244.

Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice. Cancer Res. 2010 May 25. [Epub ahead of print]

Melby SJ, Larue SJ, Lasala JM, Pal N, Lakshminarasimhachar A, Trulock EP, Kreisel D, Pasque MK, Puri V, Patterson GA, Krupnick AS. Anatomic distortion of the right coronary artery as a complication of lung transplantation. Ann Thorac Surg. 2010 Jun;89(6):2000-1.

Puri V, Garg N, Engelhardt EE, Kreisel D, Crabtree TD, Meyers BF, Patterson GA, Krupnick AS. Tumor location is not an independent prognostic factor in early stage non-small cell lung cancer. Annals of Thoracic Surgery. 2010 Apr;89(4):1053-9.

Krupnick AS, Lin X, Li W, Okazaki O, Lai M, Sugimoto S, Richardson SB, Kornfeld CG, Garbow JR, Patterson GA, Gelman AE, Kreisel D. Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology. Nature Protocols. 2009;4(1):86-93

Krupnick AS, Gelman AE, Okazaki M, Lai J, Das N, Sugimoto S, Tung TH, Richardson SB, Patterson GA, Kreisel D. The feasibility of diaphragmatic transplantation as potential therapy for treatment of respiratory failure associated with Duchenne muscular dystrophy: acute canine model. Journal of Thoracic and Cardiovascular Surgery. 2008 Jun;135(6):1398-9.

Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. J Immunol. 2005 Nov 15;175(10):6265-70.

Krupnick AS, Kreisel D, Hope A, Bradley J, Govindan R, Meyers B. Recent advances and future perspectives in the management of lung cancer. Curr Probl Surg. 2005 Aug;42(8):540-610.

Pub Med page for Alexander S. Krupnick, M.D.

Books

Kreisel D, Krupnick AS, Kaiser LR (editors). The Surgical Review: a Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000.

Chapters

Adzick NS, Krupnick AS. Surgery in the Pregnant Patient. In: Greenfield LJ, Mulholland M, Oldham KT, Zelenock GB, and Lillemoe KD (eds.). Surgery: Scientific Principles and Practice. 4th edition. Philadelphia: Lippincott Williams and Wilkins; 2005.

Krupnick AS, Shrager JB. The Mediastinum. In: Chang, Ganz, Hayes, Kinsella, Pass, Schiller, Stone and Strecher (eds.). Oncology: An Evidence-Based Approach. New York: Springer-Verlag; Chapter 44 (in press, 2004).

Krupnick AS, Adzick NS. Principles of Wound Healing. In Kreisel D, Krupnick AS, Kaiser LR (eds.). The Surgical Review: a Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000: Chapter 6, pp. 110-122.

Krupnick AS, Adzick NS. Burn Injury and Management. In: Kreisel D, Krupnick AS, Kaiser LR (eds.). The Surgical Review: A Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000: Chapter 7, pp. 123-138.

Adzick NS, Krupnick AS. Surgery in the Pregnant Patient. In: Greenfield LJ, Mulholland M, Oldham KT, Zelenock GB, and Lillemoe KD (eds.). Surgery: Scientific Principles and Practice. 3rd edition. Philadelphia: Lippincott Williams and Wilkins; 2001: Chapter 104.

Krupnick AS, Adzick NS. Research in Fetal Surgery. In: Souba W, Wilmore D (eds.). Surgical Research. Academic Press; 2001: Chapter 76, pp. 1065-1079.